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Here's what most people notice first with joint symptoms in chronic GVHD:

The earliest joint symptoms often include:

- Morning stiffness and achiness

- Decreased range of motion

- Tightness in joints, especially hands/wrists

- Muscle weakness near affected joints

- Joint tenderness when moving

Over time, symptoms may progress to:

- Pain with movement

- Contractures (permanent tightening)

- Limited mobility

- Joint swelling

- Need for assistive devices

Early treatment is important to prevent permanent joint damage. Work with your transplant team to manage symptoms using medications, physical therapy, and joint protection strategies.