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How can GVHD affect the lungs?

GVHD can affect the lungs when donor cells attack healthy lung tissue, triggering chronic inflammation that damages the airways. Over time, this inflammation can lead to scarring and narrowing of the small airways, making breathing more difficult.

About 14 percent of people with chronic GVHD Show Full Answer

How can GVHD affect the lungs?

GVHD can affect the lungs when donor cells attack healthy lung tissue, triggering chronic inflammation that damages the airways. Over time, this inflammation can lead to scarring and narrowing of the small airways, making breathing more difficult.

About 14 percent of people with chronic GVHD develop bronchiolitis obliterans syndrome (BOS), the most common lung complication. Other conditions like organizing pneumonia and interstitial lung disease can also occur.

Common symptoms include:
* Persistent dry cough lasting more than two to four weeks
* Shortness of breath or difficulty breathing
* Chest tightness or trouble breathing deeply
* Wheezing or crackling sounds when breathing

Some people with BOS may not notice symptoms right away—about 20 percent have no symptoms initially. As the condition progresses, symptoms typically worsen and can make physical activity harder, leading to fatigue and reduced stamina.

If you notice any new or worsening breathing problems, contact your healthcare team immediately. Early diagnosis and treatment can help prevent further lung damage and maintain quality of life.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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