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What is Graft-Versus-Host Disease?

GVHD is a complication that can develop after an allogeneic stem cell transplant (also called a bone marrow transplant), which uses donor cells to treat blood cancers like leukemia or lymphoma.

In GVHD, the donated immune cells (the graft) mistakenly identify healthy cells in your body Show Full Answer

What is Graft-Versus-Host Disease?

GVHD is a complication that can develop after an allogeneic stem cell transplant (also called a bone marrow transplant), which uses donor cells to treat blood cancers like leukemia or lymphoma.

In GVHD, the donated immune cells (the graft) mistakenly identify healthy cells in your body (the host) as foreign invaders and begin attacking them. This happens when transplanted T cells—a type of white blood cell that normally fights infections and cancer—recognize your healthy cells as harmful and start to attack your tissues and organs.

Why Does It Happen?

After a transplant, donated cells form a new immune system in your body. While these cells can help fight cancer, they may also attack healthy tissue, causing damage that can range from mild to life-threatening.

When Can It Occur?

GVHD can develop at any time after your transplant. Healthcare teams try to prevent it by carefully matching donors and prescribing immunosuppressive medications before and after transplant.

Understanding GVHD is important for managing your health after a stem cell transplant.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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